Why the study?
Does miconazole inhibit HERG K+ channels in HEK293 cells?
Population
Human embryonic kidney 293 cells heterologously expressing human ether-a-go-go-related gene K+ channels
Comparison
Miconazole (0.4-40 microM) vs Controls (no miconazole)
Design
Preclinical
Authors
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Supports mechanistic basis for miconazole-associated QT prolongation; leaves open clinical relevance pending human data.
Does miconazole inhibit HERG K+ channels in HEK293 cells?
Miconazole directly inhibits HERG K+ channels by binding to the pore-S6 region, providing a mechanistic explanation for its association with acquired long QT syndrome.
Kikuchi et al. (2005) studied this question.
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