December 16, 1997Circulation

Halothane Protects Cardiomyocytes Against Reoxygenation-Induced Hypercontracture

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Why the study?

Does halothane prevent reoxygenation-induced hypercontracture in isolated rat cardiomyocytes?

Population

Isolated adult rat cardiomyocytes subjected to simulated ischemia-reperfusion

Comparison

0.4 mmol/L halothane added on reoxygenation vs Absence of halothane (control group)

Design

Preclinical

Authors

WSW. SchlackGeneral / Preventive / Lipids YLYury LadilovMedizinische Hochschule Brandenburg Theodor Fontane CBC. BalserJustus-Liebig-Universität Gießen

Discussion

Member takes

Implication

Halothane blunts reoxygenation injury in isolated cardiomyocytes; leaves open any in vivo or clinical cardioprotective role.

Structured PICO

Does halothane prevent reoxygenation-induced hypercontracture in isolated rat cardiomyocytes?

Population

Isolated adult rat cardiomyocytes subjected to simulated ischemia-reperfusion (anoxia at pH 6.4, reoxygenation at pH 7.4)

Intervention

0.4 mmol/L halothane added on reoxygenation

Comparator

Absence of halothane (control group)

Outcome

Development of hypercontracture (measured microscopically as % of end-ischemic cell length) and oscillations of cytosolic Ca2+surrogate

Halothane protects isolated rat cardiomyocytes against reoxygenation-induced hypercontracture by preventing intracellular Ca2+ oscillations during the early phase of reoxygenation.

Cite This Study

Schlack et al. (1997) studied this question.

synapsesocial.com/papers/6a83a4cd53408ed95e4d7b9c https://doi.org/10.1161/01.cir.96.12.4372

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Halothane Protects Cardiomyocytes Against Reoxygenation-Induced Hypercontracture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Halothane Protects Cardiomyocytes Against Reoxygenation-Induced Hypercontracture

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider