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June 1, 2002The British Journal of PsychiatryOpen Access

Rapid tranquillisation: Time for a reappraisal of options for parenteral therapy

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Why the study?

What are the recommended alternatives to intramuscular droperidol for rapid parenteral tranquillisation?

Population

Patients requiring rapid parenteral tranquillisation for acutely disturbed behaviour

Comparison

Parenteral benzodiazepines or rapid-acting… vs Droperidol or haloperidol

Design

Review

Authors

RMR. Hamish McAllister‐WilliamsCumbria Northumberland Tyne and Wear NHS Foundation TrustIFI. Nicol FerrierNewcastle University

Discussion

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Overview

May support benzodiazepine preference for rapid tranquillisation; leaves open need for randomized comparisons.

Structured PICO

What are the recommended alternatives to intramuscular droperidol for rapid parenteral tranquillisation?

P
Population
Patients requiring rapid parenteral tranquillisation for acutely disturbed behaviour
I
Intervention
Parenteral benzodiazepines or rapid-acting intramuscular atypical antipsychotic agents
C
Comparator
Droperidol or haloperidol
O
Outcome
Safety and efficacy of rapid tranquillisation optionssafety

Due to cardiotoxicity and extrapyramidal side-effects associated with haloperidol, parenteral benzodiazepines are recommended as the mainstay for rapid tranquillisation.

Cite This Study

McAllister‐Williams et al. (2002) studied this question.

synapsesocial.com/papers/6a83a4e7b0b8dfdc4c62c873https://doi.org/10.1192/bjp.180.6.485
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Post-Mortem Antipsychotic Drug Concentrations and Unexplained Deaths1994 · 75 citations
  2. 2Comparison of the Frequency of Behavioral Disinhibition on Alprazolam, Clonazepam, or No Benzodiazepine in Hospitalized Psychiatric Patients2000 · 43 citations
  3. 3Acute high-dose parenteral haloperidol treatment of psychosis1979 · 82 citations
  4. 4Rapid Tranquillisation1992 · 125 citations
  5. 5The Safe Use of High Dose Neuroleptics in a Psychiatric Intensive Care Unit1986 · 19 citations