October 15, 1990Biochemical JournalOpen Access

Characterization of an actin-myosin head interface in the 40–113 region of actin using specific antibodies as probes

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Population

In vitro biochemical model using filamentous actin and skeletal-muscle myosin subfragment 1

Design

Preclinical

Authors

JLJérôme LabbéHôpital Saint- Camille CMCaroline MéjeanCentre de Coopération Internationale en Recherche Agronomique pour le Développement YBYves BenyaminCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

Does not inform clinical practice; leaves open targeted modulation of the multisite interface in future studies.

Structured PICO

Population

In vitro biochemical model using filamentous actin and skeletal-muscle myosin subfragment 1

Intervention

Cross-linking with 1-ethyl-3-[3-(dimethylamino)propyl]carbodi-imide and probing with specific antibodies against actin sequences

Outcome

Characterization of the actin-myosin head interfacesurrogate

This basic science study identifies two distinct regions (18-28 and 95-113) involved in the actin-myosin interface, supporting a multisite interaction model.

Cite This Study

Labbé et al. (1990) studied this question.

synapsesocial.com/papers/6a83a53fa3cef8348e9967ef https://doi.org/10.1042/bj2710407

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Characterization of an actin-myosin head interface in the 40–113 region of actin using specific antibodies as probes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of an actin-myosin head interface in the 40–113 region of actin using specific antibodies as probes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider