Chronic hypocalcaemia due to non-compliance with supplementation can manifest with acute neurological symptoms such as seizures decades after thyroidectomy, highlighting the importance of long-term follow-up.
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Case supports calcium repletion for late hypocalcemic seizures post-thyroidectomy; leaves optimal long-term monitoring open.
We report a rare case of late-onset hypocalcaemia presenting with seizure in a female patient, occurring approximately 25 years after a total thyroidectomy. Initial investigations ruled out intracranial pathology, and biochemical analysis confirmed severe hypocalcaemia. The patient responded to intravenous calcium gluconate infusion, with subsequent stabilisation on oral calcium therapy. Notably, the patient had been non-compliant with long-term calcium supplementation. This report underscores that chronic hypocalcaemia can manifest with acute neurological symptoms such as seizures and highlights the importance of long-term follow-up for post-thyroidectomy patients.
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Hamid et al. (2025) studied this question.
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