Why the study?
Does halothane affect spontaneous contractile waves and stimulated contractions in isolated rat and dog heart cells?
Does halothane affect spontaneous contractile waves and stimulated contractions in isolated rat and dog heart cells?
Halothane induces a negative inotropic effect in isolated heart cells by enhancing calcium release from the sarcoplasmic reticulum, eventually reducing its calcium stores.
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Supports halothane negative inotropy via SR calcium in animal myocytes; leaves open translation to intact hearts or clinical anesthesia.
Wheeler et al. (1990) studied this question.
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