Population
Intact rat ventricular trabeculae, paced at 0.5 Hz and 30 degrees C with a bathing extracellular Ca2+…
Comparison
Halothane at varying doses vs Lowered extracellular Ca2+ concentration and…
Design
Preclinical
Authors
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Halothane's dose-dependent Ca2+ effects warrant caution in cardiac anesthesia; hypothesis-generating in animals, human translation remains open.
Halothane exerts its cardiodepressant effects through dose-dependent mechanisms involving both reduced calcium sensitivity of the contractile apparatus and decreased intracellular calcium transients.
Jiang et al. (1998) studied this question.
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