July 1, 1995Anesthesia & Analgesia
Effects of Halothane on Calcium2+-Activated Tension of the Contractile Proteins and Calcium2+ Uptake and Release by the Sarcoplasmic Reticulum in Skinned Human Myocardial Fibers
Why the study?
Does halothane affect Ca2+-activated tension and Ca2+ uptake/release in skinned human myocardial fibers?
Population
Skinned human myocardial fibers from left ventricular muscle samples obtained from patients undergoing…
Comparison
Halothane (1%-3%) vs Control solution (no halothane)
Design
Preclinical
Authors
Discussion
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Implication
May impair contractility via SR calcium handling in animal myocardium; hypothesis-generating for human fibers and should not yet change practice.
Structured PICO
Does halothane affect Ca2+-activated tension and Ca2+ uptake/release in skinned human myocardial fibers?
P
Population
Skinned human myocardial fibers from left ventricular muscle samples obtained from patients undergoing aortocoronary bypass operations
I
Intervention
Halothane (1%-3%)
C
Comparator
Control solution (no halothane)
O
Outcome
Ca2+-activated tension development of the contractile proteins and Ca2+ uptake and release by the sarcoplasmic reticulumsurrogate
Halothane depresses myocardial contractility primarily by decreasing calcium uptake by the sarcoplasmic reticulum and decreasing activation of contractile proteins.
Cite This Study
Sivarajan et al. (1995) studied this question.