Key result
Increasing calcium concentration antagonized the depressant effect of 0.5% halothane on the contractility of cat papillary muscle, restoring maximal force.
Population
cat papillary muscle
Comparison
Increasing [Ca++] in the external bathing medium vs 0.5 per cent halothane without increased [Ca++]
Design
Preclinical
Authors
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May guide experimental reversal of halothane depression; leaves open clinical translation in anesthesia.
Halothane-induced myocardial depression can be reversed by increasing extracellular calcium, suggesting the anesthetic interferes with calcium availability or contractile protein response rather than causing metabolic depression.
Henry L. Price (1974) studied Myocardial depression caused by halothane. Calcium ([Ca++]) vs. Without increased [Ca++] was evaluated on Contractility of cat papillary muscle. Increasing calcium concentration antagonized the depressant effect of 0.5% halothane on the contractility of cat papillary muscle, restoring maximal force.
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