What question did this study set out to answer?

To assess the independent associations of L-DOPA-induced dyskinesias and motor fluctuations, including their respective severity and daily duration, with health-related quality of life in Parkinson's disease.

September 20, 2017European Journal of NeurologyOpen Access

L‐DOPA‐induced dyskinesias, motor fluctuations and health‐related quality of life: the COPARK survey

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Authors

SPSantiago Perez‐Lloret LNLaurence Nègre‐Pagès PDPhilippe Damier

Discussion

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Overview

Cross-sectional study finds that dyskinesia severity and motor fluctuation duration independently degrade quality of life in Parkinson's disease, highlighting distinct therapeutic targets.

Key Points

To assess the independent associations of L-DOPA-induced dyskinesias and motor fluctuations, including their respective severity and daily duration, with health-related quality of life in Parkinson's disease.
Cross-sectional analysis of N=683 patients with Parkinson's disease enrolled in the COPARK survey.
Health-related quality of life was evaluated using the 39-Item Parkinson's Disease Questionnaire (PDQ-39) as the primary outcome and the SF-36 survey.
Daily duration and severity of dyskinesias and motor fluctuations were quantified using items from the Unified Parkinson's Disease Rating Scale (UPDRS) sections II and IV.
Motor fluctuations occurred in 35% of patients (n=235) and L-DOPA-induced dyskinesias occurred in 27% (n=182).
Both dyskinesias and motor fluctuations were significantly associated with worse PDQ-39 total scores after adjusting for one another.
Dyskinesia severity and motor fluctuation duration independently worsened PDQ-39 scores, whereas SF-36 physical scores were impaired exclusively by motor fluctuation severity.

Cite This Study

Perez‐Lloret et al. (2017) studied this question.

synapsesocial.com/papers/6a83a71a4b7d31ae448dcbd4 https://doi.org/10.1111/ene.13466

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September 20, 2017European Journal of NeurologyOpen Access

L‐DOPA‐induced dyskinesias, motor fluctuations and health‐related quality of life: the COPARK survey

View Full Paper

Ask AI

Bookmark

Authors

SPSantiago Perez‐Lloret LNLaurence Nègre‐Pagès PDPhilippe Damier

Discussion

Member takes

Overview

Cross-sectional study finds that dyskinesia severity and motor fluctuation duration independently degrade quality of life in Parkinson's disease, highlighting distinct therapeutic targets.

Key Points

To assess the independent associations of L-DOPA-induced dyskinesias and motor fluctuations, including their respective severity and daily duration, with health-related quality of life in Parkinson's disease.
Cross-sectional analysis of N=683 patients with Parkinson's disease enrolled in the COPARK survey.
Health-related quality of life was evaluated using the 39-Item Parkinson's Disease Questionnaire (PDQ-39) as the primary outcome and the SF-36 survey.
Daily duration and severity of dyskinesias and motor fluctuations were quantified using items from the Unified Parkinson's Disease Rating Scale (UPDRS) sections II and IV.
Motor fluctuations occurred in 35% of patients (n=235) and L-DOPA-induced dyskinesias occurred in 27% (n=182).
Both dyskinesias and motor fluctuations were significantly associated with worse PDQ-39 total scores after adjusting for one another.
Dyskinesia severity and motor fluctuation duration independently worsened PDQ-39 scores, whereas SF-36 physical scores were impaired exclusively by motor fluctuation severity.

Cite This Study

Perez‐Lloret et al. (2017) studied this question.

synapsesocial.com/papers/6a83a71a4b7d31ae448dcbd4 https://doi.org/10.1111/ene.13466

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