What question did this study set out to answer?

To determine whether regenerating adult mammalian retinal ganglion cell axons can establish organized synapses when directed to an atypical brain target, the cerebellum.

April 1, 1992Journal of NeuroscienceOpen Access

Synapse formation and preferential distribution in the granule cell layer by regenerating retinal ganglion cell axons guided to the cerebellum of adult hamsters

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Authors

TZTJ Zwimpfer AAAJ AguayoMontreal General Hospital GBGM BrayMontreal General Hospital

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Implication

Experimental study reveals selective synaptogenesis by rerouted retinal axons in the cerebellar granule layer of adult hamsters, indicating non-random wiring during central nervous system repair.

Key Points

To determine whether regenerating adult mammalian retinal ganglion cell axons can establish organized synapses when directed to an atypical brain target, the cerebellum.
Guided regenerating retinal ganglion cell axons of adult hamsters into the cerebellum using peripheral nerve grafts.
Evaluated axonal trajectories and synaptic connections 2 to 9 months post-grafting using anterograde horseradish peroxidase tracing and electron microscopy.
Regenerating retinal axons extended up to 650 µm into the cerebellar cortex, with more than 95% of labeled terminals and synapses selectively localized to the granule cell layer.
Retinocerebellar terminals in the granule cell layer were larger and formed more synapses than those typically observed in the superior colliculus, independent of graft location or reactive gliosis.

Cite This Study

Zwimpfer et al. (1992) studied this question.

synapsesocial.com/papers/6a83a82c4b7d31ae448dcc47 https://doi.org/10.1523/jneurosci.12-04-01144.1992

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Implication

Experimental study reveals selective synaptogenesis by rerouted retinal axons in the cerebellar granule layer of adult hamsters, indicating non-random wiring during central nervous system repair.

Synapse formation and preferential distribution in the granule cell layer by regenerating retinal ganglion cell axons guided to the cerebellum of adult hamsters

Discussion

Member takes

Implication

Key Points

Cite This Study

Synapse formation and preferential distribution in the granule cell layer by regenerating retinal ganglion cell axons guided to the cerebellum of adult hamsters

Discussion

Member takes

Implication

Key Points

Cite This Study

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