What question did this study set out to answer?

To determine whether anti-inflammatory and painkiller drugs alter bacterial growth and overcome antibiotic resistance in Proteus mirabilis isolates.

May 25, 2023BiomedicineOpen Access

Bacterial growth and antibiotic sensitivity of Proteus mirabilis treated with anti-inflammatory and painkiller drugs

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Authors

MMMohsin Rasheed MohsinAlsalam University College BABahaa Abdullah Laftaah Al-RubaiiUniversity of Baghdad

Discussion

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Implication

In vitro study demonstrates synergistic growth inhibition of clinical Proteus mirabilis isolates by combined antibiotics and analgesics, highlighting potential non-antibiotic adjuvants.

Key Points

To determine whether anti-inflammatory and painkiller drugs alter bacterial growth and overcome antibiotic resistance in Proteus mirabilis isolates.
Screened 119 urine samples from Baghdad hospitals, identifying Proteus mirabilis via the Vitek-2 compact system and 16S rRNA gene PCR amplification.
Tested antibiotic susceptibility and assessed synergy between antibiotics and anti-inflammatory or painkiller drugs (dexamethasone, nefopam, olfen, paracetamol, piroxicam) using the Kirby-Bauer method against extensively drug-resistant isolates.
Identified P. mirabilis in 35 of 119 samples (29.41%), with high baseline resistance to minocycline (71.40%), ticarcillin (68.57%), trimethoprim/sulfamethoxazole (65.70%), and ticarcillin/clavulanic acid (57.10%).
Observed complete growth inhibition of P. mirabilis when combining antibiotics with olfen (75 mg/2 ml) or paracetamol (500 mg/5 ml), despite these non-antibiotic drugs exhibiting no antibacterial activity on their own.

Cite This Study

Mohsin et al. (2023) studied this question.

synapsesocial.com/papers/6a83a99c20cfb2932ffe199e https://doi.org/10.51248/.v43i02.2693

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Implication

In vitro study demonstrates synergistic growth inhibition of clinical Proteus mirabilis isolates by combined antibiotics and analgesics, highlighting potential non-antibiotic adjuvants.

Bacterial growth and antibiotic sensitivity of Proteus mirabilis treated with anti-inflammatory and painkiller drugs

Discussion

Member takes

Implication

Key Points

Cite This Study

Bacterial growth and antibiotic sensitivity of Proteus mirabilis treated with anti-inflammatory and painkiller drugs

Discussion

Member takes

Implication

Key Points

Cite This Study

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