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This review highlights the mechanistic links between insulin resistance and endothelial dysfunction, providing context for the increased cardiovascular risk observed in metabolic syndrome and diabetes.
In this article, we review several mechanisms by which insulin resistance is related to endothelial dysfunction. The mechanisms we discuss may explain the high prevalence of cardiovascular disease found in people with the metabolic syndrome and diabetes mellitus.
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Sriraman et al. (2004) studied this question.
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