Population
p130Cas substrate domain (CasSD) protein model
Design
Preclinical
Authors
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CasSD disorder may refine cardiac mechanosensing hypotheses; leaves open validation in human cardiomyocytes and clinical translation.
The p130Cas substrate domain is intrinsically disordered without a stable compact structure, suggesting it functions with LIM domain proteins to regulate phosphorylation and mechanosensing.
Hotta et al. (2014) studied this question.
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