What question did this study set out to answer?

To evaluate the relationships between varying intravenous glucose loads, acute and total insulin secretory responses, and the glucose disappearance rate.

September 1, 1971The Journal of Clinical Endocrinology & Metabolism

Relationships Between Intravenous Glucose Loads, Insulin Responses and Glucose Disappearance Rate1

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Authors

RLRoger L. LernerUniversity of Southern California DPDaniel PorteUniversity of California, San Diego

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Implication

Interventional study demonstrates acute insulin response drives glucose disappearance rate in healthy adults, indicating stored insulin limits clearance.

Key Points

To evaluate the relationships between varying intravenous glucose loads, acute and total insulin secretory responses, and the glucose disappearance rate.
Administered rapid intravenous glucose injections ranging from 0.5 to 40 g to healthy subjects.
Measured 3–5 min peak absolute and incremental plasma glucose, early insulin response (3–5 min incremental levels), total incremental insulin area, and glucose disappearance rate (Kg).
Peak plasma glucose correlated linearly with injected dose (r = +0.98), while the early insulin response increased nonlinearly and total incremental insulin area scaled linearly (r = +0.85).
Glucose disappearance rate (Kg) was a nonlinear function of dose, correlating strongly with acute insulin response (r = +0.72 across all doses; r = +0.66 at 20 g) but not with total insulin output (r = +0.04 at 20 g).

Cite This Study

Lerner et al. (1971) studied this question.

synapsesocial.com/papers/6a83b0ab8df3fed3c85bce9e https://doi.org/10.1210/jcem-33-3-409

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Implication

Interventional study demonstrates acute insulin response drives glucose disappearance rate in healthy adults, indicating stored insulin limits clearance.

Relationships Between Intravenous Glucose Loads, Insulin Responses and Glucose Disappearance Rate1

Discussion

Member takes

Implication

Key Points

Cite This Study

Relationships Between Intravenous Glucose Loads, Insulin Responses and Glucose Disappearance Rate1

Discussion

Member takes

Implication

Key Points

Cite This Study

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