Why the study?
Does ticagrelor improve atherosclerotic plaque stability in apolipoprotein-E-deficient mice?
Does ticagrelor improve atherosclerotic plaque stability in apolipoprotein-E-deficient mice?
Ticagrelor demonstrates plaque-stabilizing effects in a mouse model of advanced atherosclerosis, potentially through reduced oxLDL uptake and inhibition of macrophage apoptosis.
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Ticagrelor may stabilize plaques in this mouse model; hypothesis-generating and leaves open any clinical translation pending human studies.
Preusch et al. (2016) studied this question.
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