What question did this study set out to answer?

To evaluate baseline HbA1c as a predictor of incident diabetes and examine the comparative effects of metformin and intensive lifestyle intervention on diabetes diagnosed by an HbA1c threshold of ≥6.5%.

October 21, 2014Diabetes CareOpen Access

HbA1c as a Predictor of Diabetes and as an Outcome in the Diabetes Prevention Program: A Randomized Clinical Trial

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Implication

Randomized trial demonstrates metformin and lifestyle interventions reduce HbA1c-defined diabetes in high-risk adults, indicating comparable efficacy across prevention strategies.

Key Points

To evaluate baseline HbA1c as a predictor of incident diabetes and examine the comparative effects of metformin and intensive lifestyle intervention on diabetes diagnosed by an HbA1c threshold of ≥6.5%.
Randomized clinical trial (Diabetes Prevention Program [DPP] with 3.2-year duration and 10-year follow-up in DPPOS) enrolling 3,234 adults at high risk of diabetes assigned to placebo, metformin, or intensive lifestyle intervention.
Assessed outcomes in a subset of 2,765 participants who were confirmed free of diabetes at baseline using fasting plasma glucose, 2-h postload glucose, and 2010 ADA HbA1c criteria.
Baseline HbA1c strongly predicted the development of incident diabetes across all randomized treatment arms.
During the initial DPP phase, diabetes incidence defined by HbA1c ≥6.5% was reduced by 44% with metformin and 49% with lifestyle intervention compared to placebo.
Over long-term follow-up, cumulative diabetes incidence was reduced by 38% with metformin and 29% with lifestyle intervention, showing similar preventive efficacy between treatments when using HbA1c criteria.

Cite This Study

A 2014 study studied this question.

synapsesocial.com/papers/6a83b6026eaad3b729ee7d5c https://doi.org/10.2337/dc14-0886

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Implication

Randomized trial demonstrates metformin and lifestyle interventions reduce HbA1c-defined diabetes in high-risk adults, indicating comparable efficacy across prevention strategies.

HbA1c as a Predictor of Diabetes and as an Outcome in the Diabetes Prevention Program: A Randomized Clinical Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

HbA1c as a Predictor of Diabetes and as an Outcome in the Diabetes Prevention Program: A Randomized Clinical Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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