Population
A7r5 cells, a cell line derived from rat aortic vascular smooth muscle cells (VSMC)
Design
Preclinical
Follow-up
up to 48 hours
Authors
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K(Ca)3.1 emerges as a candidate target in proliferative vascular disease; leaves open translation from rodent cells to human therapeutics.
Upregulation of rK(Ca)3.1 via the Raf/MEK/ERK pathway promotes vascular smooth muscle cell proliferation, highlighting a potential pharmacological target for cardiovascular diseases characterized by abnormal cell proliferation.
Si et al. (2006) studied this question.
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