What question did this study set out to answer?

To evaluate the efficacy in local tumor control, survival outcomes, and associated toxicity of single-fraction stereotactic body radiotherapy (SBRT) for unresectable pancreatic adenocarcinoma.

January 2, 2009Cancer

Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas

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Authors

DCDaniel T. ChangSimon Fraser University DSDevin SchellenbergBC Cancer Agency JSJohn ShenComprehensive Cardiovascular

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Implication

Cohort study demonstrates high local control alongside late toxicities in unresectable pancreatic adenocarcinoma, indicating a need for quality assurance.

Key Points

To evaluate the efficacy in local tumor control, survival outcomes, and associated toxicity of single-fraction stereotactic body radiotherapy (SBRT) for unresectable pancreatic adenocarcinoma.
Evaluated 77 patients with unresectable, medically inoperable, metastatic, or locally recurrent pancreatic adenocarcinoma treated with a single 25-Gy fraction of SBRT.
Most patients (96%, n=74) received gemcitabine-based chemotherapy, and 21% (n=16) received prior fractionated radiotherapy (45–54 Gy).
Followed patients for a median of 6 months overall (12 months among survivors) to monitor freedom from local progression, progression-free survival, overall survival, and toxicity.
Freedom from local progression was 91% at 6 months and 84% at 12 months, with no significant difference by tumor site (head/uncinate 91% vs body/tail 86%, P = .52).
Overall survival was 56% at 6 months and 21% at 12 months; 6-month progression-free survival was higher in nonmetastatic versus metastatic disease (28% vs 15%, P = .05).
Acute grade ≥2 toxicity occurred in 5% of patients, while cumulative grade ≥2 late toxicity reached 11% at 6 months and 25% at 12 months, with grade ≥3 late toxicity occurring in 9%.

Cite This Study

Chang et al. (2009) studied this question.

synapsesocial.com/papers/6a83b714a3cef8348e996ce2 https://doi.org/10.1002/cncr.24059

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Implication

Cohort study demonstrates high local control alongside late toxicities in unresectable pancreatic adenocarcinoma, indicating a need for quality assurance.

Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas

Discussion

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Implication

Key Points

Cite This Study

Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas

Discussion

Member takes

Implication

Key Points

Cite This Study

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