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March 20, 2014BioMedical Engineering OnLineOpen Access

Effect of leaflet-to-chordae contact interaction on computational mitral valve evaluation

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Population

2 computational virtual mitral valve models created using 3D transesophageal echocardiography data from 2…

Comparison

Computational dynamic finite element simulation… vs Computational MV simulation without…

Design

Preclinical

Authors

YRYonghoon RimThe University of Texas Health Science Center at HoustonDMDavid D. McPhersonThe University of Texas Health Science Center at HoustonHKHyunggun KimYonsei University

Discussion

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Implication

Requires leaflet-to-chordae contact in mitral valve models to avoid underestimating regurgitant orifice area; extends computational fidelity but leaves clinical translation open.

Structured PICO

P
Population
2 computational virtual mitral valve (MV) models created using 3D transesophageal echocardiography data from 2 patients (1 with normal MV without mitral regurgitation, 1 with pathologic MV with mitral regurgitation)
I
Intervention
Computational dynamic finite element simulation of MV function incorporating full leaflet-to-chordae contact interaction
C
Comparator
Computational MV simulation without leaflet-to-chordae contact interaction (leaflet-to-leaflet contact only)
O
Outcome
Degree of leaflet coaptation and physical realism of contact interactions during systolesurrogate

Incorporating leaflet-to-chordae contact interactions in computational mitral valve models is essential for accurately quantifying leaflet coaptation and the severity of mitral regurgitation.

Limitations

  • Utilized previously published material characteristic data
  • Assumed homogeneous thickness and material behavior of MV tissue
  • Purely structural analysis without fully incorporating blood fluid effects on normal and shear pressure distribution

Cite This Study

Rim et al. (2014) studied this question.

synapsesocial.com/papers/6a83ba402ccfc61f58b05b4ehttps://doi.org/10.1186/1475-925x-13-31

Topics

Mitral valve intervention
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic Simulation Pericardial Bioprosthetic Heart Valve Function2006 · 61 citations
  2. 2Biaxial mechanical behavior of excised porcine mitral valve leaflets1995 · 192 citations
  3. 3A Constitutive Law for Mitral Valve Tissue1998 · 207 citations
  4. 4Anatomy of the mitral valve2002 · 185 citations
  5. 5The Biomechanical Effects of Fatigue on the Porcine Bioprosthetic Heart Valve2001 · 59 citations