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Passive administration of heterologous antibody to guinea pigs infected with Herpes simplex virus type 1 and type 2 allowed a production of antisera of enhanced specificity. The anti Herpes simplex virus type 1 serum produced was of high specificity and potency and showed only minor reactions with Herpes simplex virus type 2. The anti-Herpes simplex virus type 2 serum produced was of moderate specificity, but clearly differentiated between Herpes simplex virus type 1 and type 2 in different immunological reactions. The procedure described is a simple method whereby relatively specific antisera for typing of Herpes simplex virus type 1 and type 2 strains can be produced.
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Stig Jeansson (1974) studied this question.
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