Why the study?
Does recombinant human growth hormone therapy improve bone density in adults with isolated GH deficiency?
Population
12 adults (10 males and 2 females) with isolated growth hormone (GH) deficiency
Comparison
Recombinant human growth hormone as a single… vs Placebo
Design
RCT, Double blind
Follow-up
1 year
Authors
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Supports GH replacement for bone density gains in isolated GH deficiency; extends RCT evidence to 1-year maintenance.
Does recombinant human growth hormone therapy improve bone density in adults with isolated GH deficiency?
Recombinant human growth hormone therapy significantly increases spinal and forearm bone mineral density in adults with isolated GH deficiency, demonstrating its role in maintaining adult skeletal integrity.
O’Halloran et al. (1993) studied this question.
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