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December 4, 2001Proceedings of the National Academy of SciencesOpen Access

A targeted dominant negative mutation of the thyroid hormone α1 receptor causes increased mortality, infertility, and dwarfism in mice

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MKMasahiro KaneshigeMirai HospitalHSHideyo SuzukiMSD K.K. (Japan)KKKumiko KaneshigeNational Cancer Institute

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Kaneshige et al. (2001) studied this question.

synapsesocial.com/papers/6a83c3d8be3ac444ce3e96ffhttps://doi.org/10.1073/pnas.261565798
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  4. 4Impaired Interaction of Mutant Thyroid Hormone Receptors Associated with Human Hepatocellular Carcinoma with Transcriptional Coregulators**This work was supported by grants from Chang-Gung University (CMRP 737, CMRP893, NMRP 407) and the National Science Council of the Republic of China (NSC 87-2316-B-182002).2001 · 25 citations
  5. 5Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor α2000 · 163 citations