Male factor infertility is the most common cause of involuntary childlessness [1,2]. It has been estimated that approximately 15% of reproductive-age couples suffer from infertility, which has become a global concern [3]. Nevertheless, in around 30%-40% of male infertility, no known cause is identified. Oxidative stress is an important factor for development of male infertility. During normal metabolism reactive oxygen species (ROS) produced within the respiratory chain of the mitochondria have the capacity to oxidize and damage cellular constituents such as lipids, proteins and DNA.
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C. Maggioni (2020) studied this question.
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