Even sparingly soluble peptides can be perbenzylated with P4-phosphazene base/benzyl bromide. The products of type A are readily soluble in organic solvents and can be used for further modifications of the peptide framework. Debenzylation is achieved by treatment with sodium in liquid nitrogen.
No takes yet. Share an insight, caveat, or question.
Pietzonka et al. (1992) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: