Population
Bovine coronary arteries with intact endothelium (donor) and recipient coronary arterial smooth muscle cells
Comparison
Perfusate from donor vessels stimulated with… vs Basal perfusate flow, perfusate from donor…
Design
Preclinical
Authors
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Hypothesis-generating for bradykinin-mediated coronary endothelial signaling in animals; leaves open relevance to human vasoregulation.
Bradykinin stimulates the release of a transferable endothelial factor (likely a cytochrome P450 metabolite of arachidonic acid) that activates KCa channels and hyperpolarizes coronary arterial smooth muscle cells.
Gebremedhin et al. (1998) studied this question.
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