Answers are grounded in this paper and cite their sources.
Recrystallization behavior of nifedipine from the supersaturated solution containing various polymers was mainly investigated to clarify the mechanism of the supersaturation phenomena from the solid dispersions of nifedipine with enteric coating agents in JP X 2nd fluid (pH 6.8). The recrystallization of nifedipine was remarkably inhibited in the medium containing non-ionic water soluble cellulose polymers or anionic cellulose polymers (enteric coating agents). However, the inhibitory effect on the recrystallization of nifedipine was little using the other type of polymer, such as polyvinylpyrrolidone or methacrylic acidmethacrylic acid methyl ester copolymer. Microscopic observations of the shape of recrystallized nifedipine suggested that a physico chemical interaction between polymer and nifedipine, such as an adsorption of polymers on the surface of nifedipine nuclei, was a main factor affecting the crystal growth of nifedipine.
No takes yet. Share an insight, caveat, or question.
Hasegawa et al. (1985) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: