March 1, 1993Journal of VirologyOpen Access

Characterization of a glial cell line persistently infected with borna disease virus (BDV): influence of neurotrophic factors on BDV protein and RNA expression

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Population

Neuronal and astrocytic cell lines persistently infected with Borna disease virus

Comparison

Nerve growth factor treatment and exposure to C6… vs Untreated cells / comparison between neuronal…

Design

Preclinical

Authors

Discussion

Cell-specific and NGF effects on BDV replication in vitro warrant no clinical change; leaves open their role in vivo pathogenesis.

Population

Neuronal (SK-N-SH and SK-N-SHEP) and astrocytic (C6) cell lines persistently infected with Borna disease virus (BDV)

Intervention

Nerve growth factor treatment and exposure to C6 cell-secreted factors

Comparator

Untreated cells / comparison between neuronal and astrocytic cell lines

Outcome

BDV replication (production of infectious virions, BDV proteins, and RNA)surrogate

BDV replication in neural cells in vitro is influenced by cell-specific factors and neurotrophic factors like nerve growth factor.

Carbone et al. (1993) studied this question.

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