Why the study?
Does combined undersized ring annuloplasty and bileaflet chordal cutting reduce mitral regurgitation and left ventricular remodeling in a sheep model of chronic ischemic mitral regurgitation?
Population
28 sheep with chronic ischemic mitral regurgitation and left ventricular remodeling induced by…
Comparison
Combined therapy of undersized ring annuloplasty… vs Sham surgery, isolated undersized annuloplasty…
Design
Preclinical, randomized to sham surgery versus isolated undersized…
Follow-up
6.6 months
Authors
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Should not yet change ischemic MR surgery; extends preclinical support for combined annuloplasty and chordal cutting.
Does combined undersized ring annuloplasty and bileaflet chordal cutting reduce mitral regurgitation and left ventricular remodeling in a sheep model of chronic ischemic mitral regurgitation?
In a sheep model of chronic ischemic mitral regurgitation, combining undersized ring annuloplasty with subvalvular chordal cutting provided superior long-term reduction in MR and LV remodeling compared to either intervention alone.
Szymanski et al. (2012) studied this question.
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