What question did this study set out to answer?

To evaluate viral interactions, therapeutic efficacy of antiviral regimens, and the risk of viral reactivation in patients coinfected with hepatitis B and hepatitis C viruses.

July 5, 2018Journal of Clinical and Translational HepatologyOpen Access

HBV-HCV Coinfection: Viral Interactions, Management, and Viral Reactivation

View Full Paper

Ask AI

Bookmark

Authors

MMMarianna G. MaviliaHartford Hospital GWGeorge Y. WuUniversity of Chicago

Discussion

Member takes

Implication

Review uncovers elevated liver cancer risk and viral reactivation risks during antiviral therapy in HBV-HCV coinfection, highlighting the need for screening.

Key Points

To evaluate viral interactions, therapeutic efficacy of antiviral regimens, and the risk of viral reactivation in patients coinfected with hepatitis B and hepatitis C viruses.
Literature review evaluating published clinical studies on interferon-based regimens and direct-acting antivirals in HBV-HCV coinfected populations.
Coinfection accelerates disease progression and increases hepatocellular carcinoma risk compared to monoinfection, with HCV replication typically dominating over HBV replication.
Clearing or suppressing HCV without simultaneous HBV control substantially elevates the risk of HBV reactivation across both interferon and direct-acting antiviral therapies.

Cite This Study

Mavilia et al. (2018) studied this question.

synapsesocial.com/papers/6a83d235b5a613d8fb3e98b0 https://doi.org/10.14218/jcth.2018.00016

View Full Paper

Ask AI

Bookmark

Implication

Review uncovers elevated liver cancer risk and viral reactivation risks during antiviral therapy in HBV-HCV coinfection, highlighting the need for screening.

HBV-HCV Coinfection: Viral Interactions, Management, and Viral Reactivation

Discussion

Member takes

Implication

Key Points

Cite This Study

HBV-HCV Coinfection: Viral Interactions, Management, and Viral Reactivation

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider