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June 1, 2001Journal of BacteriologyOpen Access

β-Ketoacyl Acyl Carrier Protein Synthase III (FabH) Is Essential for Fatty Acid Biosynthesis in Streptomyces coelicolor A3(2)

W. Peter Revill Maureen J. Bibb Ann-Karolin Scheu Helen J. Kieser David A. Hopwood

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Abstract

The Streptomyces coelicolor fab (fatty acid biosynthesis) gene cluster (fabD-fabH-acpP-fabF) is cotranscribed to produce a leaderless mRNA transcript. One of these genes, fabH, encodes a ketoacyl synthase III that is essential to and is proposed to be responsible for initiation of fatty acid biosynthesis in S. coelicolor.

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Revill et al. (2001) studied this question.

synapsesocial.com/papers/6a83d30c8607522edd4a1450 https://doi.org/10.1128/jb.183.11.3526-3530.2001

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