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Design and synthesize europium(III) DOTA-tetraamide PARACEST complexes equipped with N-methylquinolinium moieties to evaluate their utility as redox- and pH-responsive MRI sensors.

March 15, 2012Journal of the American Chemical Society

Europium(III) DOTA-tetraamide Complexes as Redox-Active MRI Sensors

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Authors

SRS. James RatnakarAdvanced Imaging Research (United States)SVS. ViswanathanChicago Institute for Psychoanalysis ZKZoltán KovácsAdvanced Imaging Research (United States)

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Implication

In vitro experimental study demonstrates switchable PARACEST MRI signals from redox-active europium complexes, indicating potential for noninvasive imaging of metabolic redox states.

Key Points

Design and synthesize europium(III) DOTA-tetraamide PARACEST complexes equipped with N-methylquinolinium moieties to evaluate their utility as redox- and pH-responsive MRI sensors.
Synthesized europium(III) DOTA-tetraamide complexes functionalized with either one or two NAD(+)/NADH-mimicking N-methylquinolinium groups.
Evaluated chemical exchange saturation transfer (CEST) signal modulation following chemical reduction by β-NADH and across physiologically relevant pH levels.
The Eu(3+) complex bearing two quinolinium units remained largely CEST-silent in the oxidized state but turned on a CEST signal upon reduction with β-NADH.
The mono-quinolinium Eu(3+) complex displayed limited redox responsiveness but demonstrated unexpected CEST sensitivity across the physiologically relevant pH range.

Cite This Study

Ratnakar et al. (2012) studied this question.

synapsesocial.com/papers/6a83d440fd07e211f9fe1e97 https://doi.org/10.1021/ja211601k

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Implication

In vitro experimental study demonstrates switchable PARACEST MRI signals from redox-active europium complexes, indicating potential for noninvasive imaging of metabolic redox states.

Europium(III) DOTA-tetraamide Complexes as Redox-Active MRI Sensors

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Europium(III) DOTA-tetraamide Complexes as Redox-Active MRI Sensors

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