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Resolution and resolution-per-unit-time have been studied for columns from 4 to 21 mm i.d. The effects of sample size, particle diameter, and linear flow rate were determined. Greatest resolution was obtained for the largest diameter column, and it was attributed to a loading effect. In a related study, efficiency was examined as a function of column diameter for a constant amount of gel and a constant retention time. The narrower columns gave more plates, but their HETP values were also greater.
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Maldacker et al. (1971) studied this question.
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