Why the study?
Does L-arginine affect heart rate through a nitric oxide-dependent mechanism in spontaneously beating guinea pig atria?
Population
Spontaneously beating guinea pig atria
Comparison
L-arginine in increasing concentrations vs D-arginine, L-lysine, and pH adjustment/clamping
Design
Preclinical
Authors
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pH artifacts may confound L-arginine chronotropy studies; challenges NO mediation and leaves open in vivo relevance.
Does L-arginine affect heart rate through a nitric oxide-dependent mechanism in spontaneously beating guinea pig atria?
In vitro chronotropic effects of L-arginine are mediated by formulation-induced changes in extracellular pH rather than nitric oxide, which can confound biological assessments of this amino acid.
Piotr Musiałek (1999) studied this question.
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