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June 23, 2010AJP Endocrinology and Metabolism

Insulin-sensitive obesity

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Population

60 individuals with morbid obesity prior to elective surgery, divided into insulin-sensitive and…

Design

Cross-sectional

Authors

NKNora KlötingMFMathias FaßhauerADArne Dietrich

Discussion

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Overview

Visceral fat and adipose inflammation warrant consideration in obese patients with insulin resistance; leaves open causal roles and need for prospective trials.

Structured PICO

P
Population
60 individuals with morbid obesity (BMI 45 +/- 1.3 kg/m2) prior to elective surgery, divided into insulin-sensitive (IS) and insulin-resistant (IR) groups matched for age, sex, and body fat.
O
Outcome
Differences in adipose tissue biology, including fat distribution, circulating adipokines, parameters of inflammation, glucose and lipid metabolism, and adipose tissue morphology/function.surrogate

Independently of total body fat mass, increased visceral fat accumulation and adipose tissue dysfunction (inflammation and adipokine release) are associated with insulin-resistant obesity.

Cite This Study

Klöting et al. (2010) studied this question.

synapsesocial.com/papers/6a83d4d307bf35307a996eachttps://doi.org/10.1152/ajpendo.00586.2009
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