Preganglionic denervation significantly reduces angiotensin II binding sites in the superior cervical ganglia of both hypertensive and normotensive rats, suggesting these sites are associated with preganglionic nerves.
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Indicates presynaptic ANG II receptor localization in rat sympathetic ganglia; leaves open relevance to human hypertension.
In the superior cervical ganglia (SCG) binding site density of angiotensin II (ANG II) was higher in adult spontaneously hypertensive rats (SHR) (571 +/- 29 fmol/mg protein) compared to that in the adult Wistar-Kyoto rat (WKY) (375 +/- 9 fmol/mg protein, P less than 0.05). The ANG II binding density was significantly decreased in the SCG of SHR (-59%, P less than 0.01) and of WKY (-39%, P less than 0.05) after unilateral preganglionic denervation (operated v sham-operated ganglia). Part of the binding sites in the superior cervical ganglia may be present in or be associated to preganglionic nerves, and the number of these sites is higher in SHR.
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Pinto et al. (1989) studied this question.
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