January 1, 1988Journal of Hypertension
Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats
Key result
Spontaneously hypertensive rats had significantly higher angiotensin II binding site concentrations in specific brain nuclei involved in central pressor action compared to normotensive controls.
Authors
Discussion
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Implication
No clinical implications yet; leaves open translation of central angiotensin II findings from rat models to humans.
Key Points
- This study aims to investigate the density of angiotensin II binding sites in brain regions of spontaneously hypertensive rats compared to normotensive controls.
- Examined angiotensin II binding sites in 4-week-old and 14-week-old spontaneously hypertensive and normotensive Wistar-Kyoto rats.
- Utilized autoradiographic binding techniques and computerized microdensitometry for analysis.
- Compared binding site densities across specific brain nuclei.
- Both young and adult spontaneously hypertensive rats exhibited significantly higher Ang II binding site concentrations in median preoptic nucleus, subfornical organ, paraventricular nucleus, and nucleus of solitary tract compared to age-matched normotensive controls.
- Ang II binding site concentration increased with age in the paraventricular nucleus for both spontaneously hypertensive and normotensive rats.
- Binding sites in median preoptic nucleus and inferior olive decreased with age.
PICO
P
Population
Spontaneous hypertension
I
Intervention / Comparator
Spontaneously hypertensive rats (SHR) vs Normotensive Wistar-Kyoto (WKY) control rats
O
Primary Outcome
Density of angiotensin II binding sites in discrete brain nuclei
Cite This Study
Gutkind et al. (1988) studied Spontaneous hypertension. Spontaneously hypertensive rats (SHR) vs. Normotensive Wistar-Kyoto (WKY) control rats was evaluated on Density of angiotensin II binding sites in discrete brain nuclei. Spontaneously hypertensive rats had significantly higher angiotensin II binding site concentrations in specific brain nuclei involved in central pressor action compared to normotensive controls.