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During the 5 years 1973-1 977, 254 patients suspected of developing dapsone resistant leprosy were seen in the Addis Ababa area. They were drawn fr om a pool of about 1500 registered patients with lepromatous leprosy, giving an incidence of about 3% per annum (among patients at risk). Fifty-one were proved resistant by mouse foot-pad tests, and 57 more by clinicai trial. The remainder, who continued in trial treatment, conformed to the clinical pattern of those proved to be dapsone resistant. Only 2 patients were proved to be sensitive to dapsone.
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Pearson et al. (1979) studied this question.
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