What question did this study set out to answer?

To determine whether allelic variants of Fc gamma RIIA, which influence the clearance of IgG2 immune complexes, confer genetic susceptibility to systemic lupus erythematosus and lupus nephritis in African Americans.

March 1, 1996Journal of Clinical InvestigationOpen Access

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

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Authors

JSJ E SalmonIntermountain Healthcare SMSusan MillardTranslational Research Institute LSLindsey SchachterStony Brook Medicine

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Implication

Cross-sectional study finds decreased Fc gamma RIIA-H131 homozygosity in African Americans with systemic lupus erythematosus, indicating inherited risk for lupus nephritis.

Key Points

To determine whether allelic variants of Fc gamma RIIA, which influence the clearance of IgG2 immune complexes, confer genetic susceptibility to systemic lupus erythematosus and lupus nephritis in African Americans.
Conducted a two-stage cross-sectional study evaluating the distribution of Fc gamma RIIA alleles (R131 and H131) in African Americans.
Initiated a pilot study comparing 43 SLE patients against 39 healthy controls.
Followed up with a multicenter validation study analyzing 214 SLE patients and 100 non-SLE controls.
In the pilot study, 9% of SLE patients were homozygous for Fc gamma RIIa-H131 compared with 36% of controls (OR 0.18, 95% CI 0.05–0.69, P = 0.009).
Multicenter cohort analysis confirmed an altered distribution of Fc gamma RIIA alleles that was most pronounced in patients with lupus nephritis.
Trend analysis demonstrated a significant decrease in the Fc gamma RIIA-H131 genotype as the severity or likelihood of lupus nephritis increased (P = 0.0004), demonstrating a protective effect of the H131 allele.

Cite This Study

Salmon et al. (1996) studied this question.

synapsesocial.com/papers/6a83dbc7b0b8dfdc4c62dbf4 https://doi.org/10.1172/jci118552

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Implication

Cross-sectional study finds decreased Fc gamma RIIA-H131 homozygosity in African Americans with systemic lupus erythematosus, indicating inherited risk for lupus nephritis.

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

Discussion

Member takes

Implication

Key Points

Cite This Study

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

Discussion

Member takes

Implication

Key Points

Cite This Study

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