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March 1, 1985Experimental Biology and Medicine

Inactivation of Interferon by Serum and Synovial Fluids

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Population

Serum and synovial fluid samples

Comparison

Incubation with interferons-alpha, -beta, and… vs Comparison between interferon species

Design

Preclinical

Authors

POPatrick O’KellyBeaumont HospitalLTLars Lykke ThomsenUniversity of North Carolina at Chapel HillJTJeremiah G. TillesUniversity of Southern California

Discussion

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Overview

Interferon-beta stability loss may confound ex vivo assays; leaves open in vivo relevance for inflammatory models.

Structured PICO

P
Population
Serum and synovial fluid samples
I
Intervention
Incubation with interferons-alpha, -beta, and -gamma
C
Comparator
Comparison between interferon species
O
Outcome
Stability/inactivation of interferonssurrogate

Interferon-beta is significantly less stable in serum and synovial fluid compared to alpha and gamma species due to dialyzable factors.

Cite This Study

O’Kelly et al. (1985) studied this question.

synapsesocial.com/papers/6a83dcac07bf35307a996fc7https://doi.org/10.3181/00379727-178-42024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  2. 2Cell and Virus Sensitivity Studies with Recombinant Human Alpha Interferons1983 · 69 citations
  3. 3Recombinant Interferons β and γ Have a Higher Antiviral Activity than Interferon-α in Coxsackievirus B3-Infected Carrier State Cultures of Human Myocardial Fibroblasts1996 · 32 citations
  4. 4From Genetic Engineering to Preclinical Safety: A Study on Recombinant Human Interferons2025
  5. 5Safety, Tolerability, and Immunogenicity of Interferons2010 · 33 citations