January 1, 1983Journal of Interferon Research

Cell and Virus Sensitivity Studies with Recombinant Human Alpha Interferons

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Population

Human, bovine, monkey, mouse, rabbit, and hamster cell lines, and mice infected with SFV, EMC, HSV, or…

Design

Preclinical

Authors

MKMichael KrämerUniversity Hospital Bonn RDR DenninThe University of Texas MD Anderson Cancer Center CKChiara KrämerHeidelberg University

Discussion

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Implication

Subtype-specific protection in mice cautions against assuming uniform IFN-alpha activity; leaves open human efficacy differences and subtype optimization.

Structured PICO

Population

Human (WISH, HeLa, AG1732), bovine (MDBK, BT), monkey (Vero), mouse (L), rabbit (RK-13), and hamster (BHK-21) cell lines, and mice infected with SFV, EMC, HSV, or influenza viruses

Intervention

Recombinant human alpha interferons (rIFN-alpha A, B, D, F, and hybrid A/D)

Outcome

Cell sensitivity and antiviral activity (inhibitory dose50) against various virusessurrogate

Different recombinant human alpha interferons exhibit varying cell sensitivities and in vivo antiviral protective effects in mice.

Cite This Study

Krämer et al. (1983) studied this question.

synapsesocial.com/papers/6a87d1b68111c1e98f48fd5c https://doi.org/10.1089/jir.1983.3.425

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Implication

Subtype-specific protection in mice cautions against assuming uniform IFN-alpha activity; leaves open human efficacy differences and subtype optimization.

Cell and Virus Sensitivity Studies with Recombinant Human Alpha Interferons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cell and Virus Sensitivity Studies with Recombinant Human Alpha Interferons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider