Key result
Five interferon preparations protect HeLa cells against HSV-1 infection at low viral multiplicities.
Why the study?
The antiviral activity of different human interferon preparations against DNA and RNA viruses was compared to understand their protective effects.
Population
Monolayers of HeLa cells infected with HSV-1, EMC virus, poliovirus, and VSV
Design
Preclinical comparative study
Authors
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In vitro data support interferon activity vs HSV-1; leaves open clinical translation and efficacy.
Various human interferon preparations, including cloned α2 interferon, demonstrate protective antiviral activity against HSV-1 and several RNA viruses in vitro.
Muñoz et al. (1984) studied Viral infection (Herpes simplex virus type 1 and RNA viruses). Five different interferon preparations (α, β, γ, lymphoblastoid, cloned α2) was evaluated on Antiviral activity / protection of cell monolayers. Five different interferon preparations (α, β, γ, lymphoblastoid, and cloned α2) were all able to protect monolayers of HeLa cells against HSV-1 infection when low multiplicities were used.
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