Population
Mammalian cell cultures infected with vesicular stomatitis virus
Comparison
Five human interferon-alpha subtypes derived… vs Natural human buffy-coat interferon-alpha…
Design
Preclinical
Authors
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Species-specific interferon activities in cell lines warrant caution in extrapolation; leaves open optimal subtype selection for antiviral applications.
Different cloned human interferon-alpha subtypes exhibit varying degrees of species specificity and antiviral activity in mammalian cell cultures.
Weck et al. (1981) studied this question.
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