Mechanism of interferon action. Kinetics of induction of the antiviral state and protein phosphorylation in mouse fibroblasts treated with natural and cloned interferons.

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Population

Mouse L929 fibroblasts

Design

Preclinical

Authors

Discussion

May implicate P1/eIF-2α phosphorylation in IFN-α antiviral action in murine fibroblasts; hypothesis-generating for mechanistic studies.

Population

Mouse L929 fibroblasts

Intervention

Natural mouse interferon or individual cloned human interferons (IFN-alpha D, IFN-alpha A/D, IFN-alpha A, IFN-alpha D/A)

Outcome

Induction of phosphorylation of protein P1 and eIF-2 alpha, and inhibition of virus replication (vesicular stomatitis virus and reovirus)surrogate

Protein phosphorylation may play a major role in the antiviral mechanism of interferon action in mouse L929 fibroblasts.

Samuel et al. (1982) studied this question.

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