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The absolute stereochemistry of chinesin I and II has been elucidated by synthetic and spectroscopic experiments. Tetrahydrochinesin I was degraded with ozonolysis and converted into the cyclopentane derivative 5 whose absolute stereochemistry was elucidated by synthesis from (–)-linalool. Degradation of chinesin I with H2SO4 gave (S)-2-methylbutyric acid. Finally, the absolute configuration of chinesin I was established as 4R, 8S, 9R, 12R, 24S.
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Aramaki et al. (1995) studied this question.
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