What question did this study set out to answer?

To review the development, mechanisms, and synthetic applications of titanium reagents used for the alkylidenation of carboxylic and carbonic acid derivatives.

November 20, 2002Journal of the Chemical Society Perkin Transactions 1

Titanium reagents for the alkylidenation of carboxylic acid and carbonic acid derivatives

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Authors

RHRichard C. HartleyUniversity of Glasgow GMGordon J. McKiernanUniversity of Leeds

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Implication

Literature review details titanium-mediated alkylidenation of carboxylic and carbonic acid derivatives, highlighting synthetic pathways to complex alkenes.

Key Points

To review the development, mechanisms, and synthetic applications of titanium reagents used for the alkylidenation of carboxylic and carbonic acid derivatives.
Comprehensive chemical literature review spanning publications from January 1, 1993, to June 1, 2002.
Systematic categorization of organotitanium reagents and their functional scope across esters, lactones, and related carbonyl substrates.
Organotitanium reagents effectively promote carbonyl olefination on challenging carboxylic and carbonic acid derivatives that are unresponsive to classical Wittig-type methods.
Titanium-promoted alkylidenations provide mild reaction conditions and high functional-group tolerance, enabling efficient synthesis of functionalized enol ethers and sterically hindered alkenes.

Cite This Study

Hartley et al. (2002) studied this question.

synapsesocial.com/papers/6a8c2cc87239707559beedeb https://doi.org/10.1039/b009709h

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Implication

Literature review details titanium-mediated alkylidenation of carboxylic and carbonic acid derivatives, highlighting synthetic pathways to complex alkenes.

Titanium reagents for the alkylidenation of carboxylic acid and carbonic acid derivatives

No abstract yet

Discussion

Member takes

Implication

Key Points

Cite This Study

Titanium reagents for the alkylidenation of carboxylic acid and carbonic acid derivatives

No abstract yet

Discussion

Member takes

Implication

Key Points

Cite This Study

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