When the chips are down: A glycoarray consisting of oligonucleotide/carbohydrate conjugates hybridized onto a DNA chip can be used for the immobilization of oligosaccharides at extremely low concentrations (1 μM). With lectin, the lower detection limit of the device was 2–20 nm. The relative surface density of the conjugates was monitored by Cy3 fluorescence.
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Chevolot et al. (2007) studied this question.
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