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A novel palladium(II)-catalyzed cyclization of aniline-tethered alkynyl cyclohexadienones is reported. This reaction offers an atom-economical and redox-neutral access to various cyclohexenone-fused tetrahydropyrano[3,4-b]indoles with high yield and excellent enantioselectivity. Remarkably, this work represents the first example on a transition-metal-catalyzed asymmetric intramolecular aminopalladation/1,4 addition sequence.
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Chen et al. (2017) studied this question.
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