February 1, 2008Biochemistry (Moscow)

Study of the interaction between rabbit cardiac contractile and regulatory proteins. An in vitro motility assay

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Structured PICO

Population

In vitro motility assay with reconstructed thin filaments and rabbit cardiac isomyosins V1 and V3

Intervention

Cardiac isomyosin V3 (200 and 300 microg/ml)

Comparator

Cardiac isomyosin V1 (200 and 300 microg/ml)

Outcome

pCa-force relationships (isometric force estimated as the amount of alpha-actinin stopping thin filament movement and Hill coefficients of cooperativity)surrogate

In vitro motility assays demonstrate differences in force generation and cooperativity between rabbit cardiac isomyosins V1 and V3, which are concentration-dependent.

Authors

LNL. V. NikitinaInstitute of Immunology and Physiology GKGalina V. KopylovaInstitute of Immunology and Physiology DSDaniil V. ShchepkinInstitute of Immunology and Physiology

Discussion

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Implication

In vitro V1/V3 force and cooperativity differences are concentration-dependent; leaves open relevance to intact myocardium.

Cite This Study

Nikitina et al. (2008) studied this question.

synapsesocial.com/papers/6a83dfa95dc7077fe9c58c81 https://doi.org/10.1134/s0006297908020090

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Study of the interaction between rabbit cardiac contractile and regulatory proteins. An in vitro motility assay

Structured PICO

Discussion

Implication

Cite This Study

Study of the interaction between rabbit cardiac contractile and regulatory proteins. An in vitro motility assay

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider