November 1, 2002The Journal of PhysiologyOpen Access

Elucidating KChiP effects on Kv4.3 inactivation and recovery kinetics with a minimal KChiP2 isoform

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Population

Ferret heart-derived minimal KChIP2 isoform (KChIP2d) and Kv4.3 channels

Design

Preclinical

Authors

SPSangita P. PatelVA Western New York Healthcare System DCDonald L. CampbellConcordia University HSHarold C. StraussSan Francisco General Hospital

Discussion

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Implication

Does not inform arrhythmia management; leaves open isoform-specific Kv4 modulation in human repolarization.

Structured PICO

Population

Ferret heart-derived minimal KChIP2 isoform (KChIP2d) and Kv4.3 channels

Intervention

KChIP2d expression/application

Outcome

Kv4.3 channel inactivation and recovery kineticssurrogate

The minimal KChIP2d isoform demonstrates that distinct structural domains of KChIPs independently modulate Kv4 channel inactivation and recovery, highlighting mechanisms of cardiac repolarization.

Cite This Study

Patel et al. (2002) studied this question.

synapsesocial.com/papers/6a83e155b0b8dfdc4c62de4b https://doi.org/10.1113/jphysiol.2002.031856

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Elucidating KChiP effects on Kv4.3 inactivation and recovery kinetics with a minimal KChiP2 isoform

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Elucidating KChiP effects on Kv4.3 inactivation and recovery kinetics with a minimal KChiP2 isoform

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider